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Literature summary for 3.6.1.23 extracted from

  • Ariza, M.; Glaser, R.; Williams, M.
    Human herpesviruses-1 encoded dUTPases: A family of proteins that modulate dendritic cell function and innate immunity (2014), Front. Microbiol., 5, 504.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Human alphaherpesvirus 2
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-
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Human alphaherpesvirus 3
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-
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Human betaherpesvirus 6A P30007
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Human betaherpesvirus 6A GS P30007
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Human gammaherpesvirus 8 P88942
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Human gammaherpesvirus 8 type M P88942
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-

Synonyms

Synonyms Comment Organism
ORF 54
-
Human gammaherpesvirus 8
ORF8
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Human alphaherpesvirus 3
U45
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Human betaherpesvirus 6A

General Information

General Information Comment Organism
physiological function enzyme activates nuclear factor NF-kappaB through ligation of TLR2/TLR1 heterodimers. Activation of NF-kappaB is inhibited by anti-TLR2 blocking antibodies and the overexpression of dominant-negative constructs of TLR2, lacking the TIR domain, and MyD88 in human embryonic kidney 293 cells expressing TLR2/TLR1. Treatment of human dendritic cells and peripheral blood mononuclear cells with the dUTPases results in the secretion of the inflammatory cytokines IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, IL-10, and IFN-gamma Human alphaherpesvirus 2
physiological function enzyme activates nuclear factor NF-kappaB through ligation of TLR2/TLR1 heterodimers. Activation of NF-kappaB is inhibited by anti-TLR2 blocking antibodies and the overexpression of dominant-negative constructs of TLR2, lacking the TIR domain, and MyD88 in human embryonic kidney 293 cells expressing TLR2/TLR1. Treatment of human dendritic cells and peripheral blood mononuclear cells with the dUTPases results in the secretion of the inflammatory cytokines IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, IL-10, and IFN-gamma Human alphaherpesvirus 3
physiological function enzyme activates nuclear factor NF-kappaB through ligation of TLR2/TLR1 heterodimers. Activation of NF-kappaB is inhibited by anti-TLR2 blocking antibodies and the overexpression of dominant-negative constructs of TLR2, lacking the TIR domain, and MyD88 in human embryonic kidney 293 cells expressing TLR2/TLR1. Treatment of human dendritic cells and peripheral blood mononuclear cells with the dUTPases results in the secretion of the inflammatory cytokines IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, IL-10, and IFN-gamma Human betaherpesvirus 6A
physiological function enzyme activates nuclear factor NF-kappaB through ligation of TLR2/TLR1 heterodimers. Activation of NF-kappaB is inhibited by anti-TLR2 blocking antibodies and the overexpression of dominant-negative constructs of TLR2, lacking the TIR domain, and MyD88 in human embryonic kidney 293 cells expressing TLR2/TLR1. Treatment of human dendritic cells and peripheral blood mononuclear cells with the dUTPases results in the secretion of the inflammatory cytokines IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, IL-10, and IFN-gamma Human gammaherpesvirus 8