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Literature summary for 3.6.1.23 extracted from
- Properties of Leishmania major dUTP nucleotidohydrolase, a distinct nucleotide-hydrolysing enzyme in kinetoplastids (2000), Biochem. J., 346, 163-168.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dUDP | - |
Leishmania major |  |
| dUMP | - |
Leishmania major | |
| NaF | - |
Leishmania major | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0045 | - |
dUTP | - |
Leishmania major | |
| 0.17 | - |
dUDP | - |
Leishmania major | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | dependent on Mg2+ or Mn2+ for optimal activity, maximal activity at 25 mM Mg2+ | Leishmania major | |
| Mn2+ | dependent on Mg2+ or Mn2+ for optimal activity | Leishmania major | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 31420 | - |
2 * 31420, calculation from amino acid sequence | Leishmania major |
| 62850 | - |
gel filtration | Leishmania major |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dUTP + H2O | Leishmania major | enzyme is involved in controlling intracellular dUTP levels | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania major | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Leishmania major |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 44.06 | - |
- |
Leishmania major |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dUDP + H2O | - |
Leishmania major | dUMP + phosphate | - |
? | |
| dUTP + H2O | - |
Leishmania major | dUMP + diphosphate | - |
? | |
| dUTP + H2O | enzyme is involved in controlling intracellular dUTP levels | Leishmania major | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 31420, calculation from amino acid sequence | Leishmania major |
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