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Literature summary for 3.6.1.21 extracted from

  • Providenzia, R.; Bass, S.T.; Hansen, R.G.
    A pyrophosphatase from mammalian tissues specific for derivatives of ADP (1968), Biochim. Biophys. Acta, 167, 199-201.
    View publication on PubMed
Search for more literature for 3.6.1.21

Inhibitors

Inhibitors Comment Organism Structure
ADP Ki: 0.075 mM Bos taurus
ADP Ki: 0.075 mM Oryctolagus cuniculus
ADP Ki: 0.075 mM Rattus norvegicus
ATP Ki: 0.165 mM Bos taurus
ATP Ki: 0.165 mM Oryctolagus cuniculus
ATP Ki: 0.165 mM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.29
-
 ADP-Glc
-
 Rattus norvegicus
0.29
-
 ADP-Glc
-
 Bos taurus
0.29
-
 ADP-Glc
-
 Oryctolagus cuniculus
1.3
-
 ADP-Rib
-
 Rattus norvegicus
1.3
-
 ADP-Rib
-
 Bos taurus
1.3
-
 ADP-Rib
-
 Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ divalent cation required for full activity, Mg2+ at concentration of 0.4 mM most effective Rattus norvegicus
Mg2+ divalent cation required for full activity, Mg2+ at concentration of 0.4 mM most effective Bos taurus
Mg2+ divalent cation required for full activity, Mg2+ at concentration of 0.4 mM most effective Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP-sugar + H2O Rattus norvegicus
-
 AMP + sugar phosphate
-
 ?
ADP-sugar + H2O Bos taurus
-
 AMP + sugar phosphate
-
 ?
ADP-sugar + H2O Oryctolagus cuniculus
-
 AMP + sugar phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus
partial Bos taurus
partial Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
brain
-
 Oryctolagus cuniculus
-
kidney
-
 Rattus norvegicus
-
kidney
-
 Oryctolagus cuniculus
-
liver
-
 Bos taurus
-
liver
-
 Oryctolagus cuniculus
-
mammary gland
-
 Rattus norvegicus
-
mammary gland
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP-Glc + H2O
-
 Rattus norvegicus AMP + Glc-1-phosphate
-
 ?
ADP-Glc + H2O
-
 Bos taurus AMP + Glc-1-phosphate
-
 ?
ADP-Glc + H2O
-
 Oryctolagus cuniculus AMP + Glc-1-phosphate
-
 ?
ADP-Man + H2O
-
 Rattus norvegicus AMP + Man-1-phosphate
-
 ?
ADP-Man + H2O
-
 Bos taurus AMP + Man-1-phosphate
-
 ?
ADP-Man + H2O
-
 Oryctolagus cuniculus AMP + Man-1-phosphate
-
 ?
ADP-Rib + H2O
-
 Rattus norvegicus AMP + Rib-5-phosphate
-
 ?
ADP-Rib + H2O
-
 Bos taurus AMP + Rib-5-phosphate
-
 ?
ADP-Rib + H2O
-
 Oryctolagus cuniculus AMP + Rib-5-phosphate
-
 ?
ADP-sugar + H2O
-
 Rattus norvegicus AMP + sugar phosphate
-
 ?
ADP-sugar + H2O
-
 Bos taurus AMP + sugar phosphate
-
 ?
ADP-sugar + H2O
-
 Oryctolagus cuniculus AMP + sugar phosphate
-
 ?
FAD + H2O very poor substrate Rattus norvegicus AMP + FMN
-
 ?
FAD + H2O very poor substrate Bos taurus AMP + FMN
-
 ?
FAD + H2O very poor substrate Oryctolagus cuniculus AMP + FMN
-
 ?
NAD+ + H2O very poor substrate Rattus norvegicus AMP + NMN
-
 ?
NAD+ + H2O very poor substrate Bos taurus AMP + NMN
-
 ?
NAD+ + H2O very poor substrate Oryctolagus cuniculus AMP + NMN
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8 8.4 with ADP-Glc as substrate Rattus norvegicus
7.8 8.4 with ADP-Glc as substrate Bos taurus
7.8 8.4 with ADP-Glc as substrate Oryctolagus cuniculus