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Literature summary for 3.6.1.18 extracted from
- Rat intestinal nucleotide-sugar pyrophosphatase. Localization, partial purification, and substrate specificity (1985), J. Biol. Chem., 260, 7474-7480.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CDP-choline | - |
Rattus norvegicus |  |
| CoA | - |
Rattus norvegicus | |
| EDTA | irreversible inhibition | Rattus norvegicus | |
| GDP-Man | inhibits FAD diphosphatase activity | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| brush border | - |
Rattus norvegicus | 5903 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 135000 | - |
SDS-PAGE of papain-solubilized enzyme | Rattus norvegicus |
| 220000 | - |
SDS-PAGE of detergent-solubilized enzyme | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| FAD + H2O | Rattus norvegicus | - |
FMN + AMP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestinal mucosa | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.458 | - |
purified enzyme | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| FAD + H2O | - |
Rattus norvegicus | FMN + AMP | - |
? | |
| GDP-Man + H2O | EC 3.6.1.9 activity | Rattus norvegicus | Man-1-phosphate + GMP | - |
? | |
| nucleotide sugars + H2O | EC 3.6.1.9 activity | Rattus norvegicus | ? | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 55 | - |
no inactivation within 120 min | Rattus norvegicus |
| 65 | - |
inactivates | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8.5 | - |
Rattus norvegicus |
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