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Literature summary for 3.6.1.17 extracted from

  • Minelli, A.; Allegrucci, C.; Liguori, L.; Ronquist, G.
    Ecto-diadenosine polyphosphate hydrolase activity on human prostasomes (2002), Prostate, 51, 1-9.
    View publication on PubMed
Search for more literature for 3.6.1.17

Inhibitors

Inhibitors Comment Organism Structure
Ap5
-
 Homo sapiens
diadenosine 5',5'''-P1,P4-tetraphosphate
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.038
-
 Ap4A pH 7.4, 37°C Homo sapiens
0.04
-
 Ap6A pH 7.4, 37°C Homo sapiens
0.098
-
 Ap5A pH 7.4, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activated by physiological concentration, maximal activity at 2 mM Homo sapiens
Mg2+ activated by physiological concentration, maximal activity at 2 mM Homo sapiens
Mn2+ activated by physiological concentration, maximal activity at 0.1 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information spermatozoa do not possess this hydrolytic activity, but they can aquire it after fusion with prostasomes Homo sapiens
-
prostasome bound to prostasome-membranes through a GPI-anchor Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ap4A + H2O
-
 Homo sapiens ?
-
 ?
Ap5A + H2O
-
 Homo sapiens ?
-
 ?
Ap6A + H2O
-
 Homo sapiens Ap5 + AMP
-
 ?
diadenosine 5',5''-P1,P4-tetraphosphate + H2O
-
 Homo sapiens ATP + AMP
-
 ?
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
-
 Homo sapiens adenosine 5'-tetraphosphate + AMP
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8 degradation of Ap4A Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6.1 8.6 pH 6.1: about 75% of maximal activity, pH 8.6: about 10% of maximal activity, degradation of Ap4A Homo sapiens