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Literature summary for 3.6.1.17 extracted from
- Bis-(5-guanosyl) tetraphosphatase in rat tissues (1982), Biochem. J., 201, 405-410.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | 50% inhibition at 0.025 mM | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
| nucleus | activity found in cytosol and nucleus, changing separation depending on tissue | Rattus norvegicus | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Rattus norvegicus | |
| Mn2+ | required, more effective than Mg2+ | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 19900 | 22000 | gel filtration, exact MW depending on tissue | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | Rattus norvegicus | - |
ATP + AMP | - |
? | |
| P1,P4-bis(5'-guanosyl)tetraphosphate + H2O | Rattus norvegicus | - |
GTP + GMP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| intestinal mucosa | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| muscle | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | - |
Rattus norvegicus | ATP + AMP | - |
? | |
| P1,P4-bis(5'-guanosyl)tetraphosphate + H2O | - |
Rattus norvegicus | GTP + GMP | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8.5 | depending on tissue | Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.025 | - |
Ca2+ | - |
Rattus norvegicus | |
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