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Literature summary for 3.6.1.15 extracted from

  • He, Z.G.; Feng, Y.; Wang, J.; Jiang, P.X.
    The regulatory function of N-terminal AAA+ ATPase domain of eukaryote-like archaeal Orc1/Cdc6 protein during DNA replication initiation (2008), Arch. Biochem. Biophys., 471, 176-183.
    View publication on PubMed
Search for more literature for 3.6.1.15

Activating Compound

Activating Compound Comment Organism Structure
additional information the ATPase domain of Cdc6-2 retains to a great extent the origin DNA-binding activity, and likewise maintains its stimulating effect on Cdc6-3, the ATPase domain of Cdc6-1, which also stimulated the DNA-binding ability of Cdc6-3 Saccharolobus solfataricus

Inhibitors

Inhibitors Comment Organism Structure
additional information the ATPase domain of Cdc6-3, although having lost much of its DNA-binding activity from the origin, inhibits both Cdc6-1 and Cdc6-2 Saccharolobus solfataricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Saccharolobus solfataricus
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 ADP + phosphate
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 ?
additional information Saccharolobus solfataricus the N-terminal AAA+ ATPase domains of Orc1/Cdc6 proteins show DNA-binding activities and functional interactions with other Cdc6 proteins, on duplex DNA substrates derived from the origins of Sulfolobus solfataricus, overview. ATPase domain of Cdc6-2 retains both DNA-binding activity and regulating effect on that of Cdc6-3 at the origin, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Saccharolobus solfataricus ADP + phosphate
-
 ?
additional information the N-terminal AAA+ ATPase domains of Orc1/Cdc6 proteins show DNA-binding activities and functional interactions with other Cdc6 proteins, on duplex DNA substrates derived from the origins of Sulfolobus solfataricus, overview. ATPase domain of Cdc6-2 retains both DNA-binding activity and regulating effect on that of Cdc6-3 at the origin, overview Saccharolobus solfataricus ?
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 ?
additional information Cdc6-1 significantly improves DNA-binding activity at the forked substrate, but only shows a very weak ability towards the blunt DNA substrate Saccharolobus solfataricus ?
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 ?