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Literature summary for 3.6.1.13 extracted from

  • Arimori, T.; Tamaoki, H.; Nakamura, T.; Kamiya, H.; Ikemizu, S.; Takagi, Y.; Ishibashi, T.; Harashima, H.; Sekiguchi, M.; Yamagata, Y.
    Diverse substrate recognition and hydrolysis mechanisms of human NUDT5 (2011), Nucleic Acids Res., 39, 8972-8983.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.13

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
complexed with 8-oxo-dGMP, 8-oxo-dGDP and 8-oxo-dADP, hanging drop vapor diffusion method, using 0.8 M NaH2PO4/1.2M K2HPO4 and 0.1 M acetate (pH 4.5), and 0.2M ammonium acetate, 35-40% (w/v) polyethylene glycol 3350 and 0.1 M sodium citrate (pH 6.2) Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP-D-ribose + H2O Homo sapiens
-
 AMP + D-ribose 5-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UKK9
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-Sepharose 6 column chromatography, HisTrap column chromatography, and Superdex 75 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
8-oxo-dADP + H2O
-
 Homo sapiens ?
-
 ?
8-oxo-dGDP + H2O
-
 Homo sapiens ?
-
 ?
ADP-D-ribose + H2O
-
 Homo sapiens AMP + D-ribose 5-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
ADP-ribose pyrophosphatase
-
 Homo sapiens
ADPRase
-
 Homo sapiens
NUDT5
-
 Homo sapiens