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Literature summary for 3.6.1.13 extracted from
- AcMNPV ORF38 protein has the activity of ADP-ribose pyrophosphatase and is important for virus replication (2007), Virology, 361, 204-211.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of ORF38 as His6-tagged protein in Escherichia coli strain Bl21(DE3) | Autographa californica multiple nucleopolyhedrovirus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.204 | - |
ADP-ribose | pH 8.0 | Autographa californica multiple nucleopolyhedrovirus |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | absolutely required, activates at 5 mM | Autographa californica multiple nucleopolyhedrovirus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP-ribose + H2O | Autographa californica multiple nucleopolyhedrovirus | - |
AMP + D-ribose 5-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Autographa californica multiple nucleopolyhedrovirus | - |
AcMNPV, ORF38 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant His6-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography | Autographa californica multiple nucleopolyhedrovirus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP-ribose + H2O | - |
Autographa californica multiple nucleopolyhedrovirus | AMP + D-ribose 5-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADP-ribose pyrophosphatase | - |
Autographa californica multiple nucleopolyhedrovirus |
| ADPRase | - |
Autographa californica multiple nucleopolyhedrovirus |
| More | the enzyme belongs to the Nudix, nucleotide diphosphate X,pyrophosphatase superfamily | Autographa californica multiple nucleopolyhedrovirus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 6.96 | - |
ADP-ribose | pH 8.0 | Autographa californica multiple nucleopolyhedrovirus | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Autographa californica multiple nucleopolyhedrovirus |
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Release 2023.1 (January 2023)
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