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Literature summary for 3.6.1.13 extracted from

  • Carloto, A.; Costas, M.J.; Cameselle, J.C.; McLennan, A.G.; Ribeiro, J.M.
    The specific, submicromolar-K(m) ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn(2+) as activating cation and increase in K(m) for ADP-ribose, both eli (2006), Biochim. Biophys. Acta, 1760, 1545-1551.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
fluoride inhibition of Mg2+-dependent activity of ADP-ribose pyrophosphatase. the Mn2+-dependent activity is not affected by fluoride Homo sapiens
Mn2+ above 0.05 mM Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ marginally effective in activation Homo sapiens
Mg2+ strictly requires Mg2+ (more than 1 mM) or Mn2+ for full activity. Treatment with H2O2 changes the specificity of both ADP-ribose activities for the activating divalent cation, giving them a marked preference for Mn2+ and rendering them virtually inactive with Mg2+ Homo sapiens
Mn2+ strictly requires Mg2+ or Mn2+ (0.05 mM) for full activity. Treatment with H2O2 changes the specificity of both ADP-ribose activities for the activating divalent cation, giving them a marked preference for Mn2+ and rendering them virtually inactive with Mg2+ Homo sapiens
Zn2+ marginally effective in activation Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000 37000 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP-ribose + H2O Homo sapiens protective enzyme whose function is to limit the intracellular accumulation of ADP-ribose AMP + D-ribose 5-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP-ribose + H2O
-
Homo sapiens AMP + D-ribose 5-phosphate
-
?
ADP-ribose + H2O protective enzyme whose function is to limit the intracellular accumulation of ADP-ribose Homo sapiens AMP + D-ribose 5-phosphate
-
?

Synonyms

Synonyms Comment Organism
NUDT9 protein
-
Homo sapiens
submicromolar-K(m) ADP-ribose pyrophosphatase
-
Homo sapiens