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Literature summary for 3.6.1.13 extracted from
- Human placenta hydrolases active on free ADP-ribose: an ADP-sugar pyrophosphatase and a specific ADP-ribose pyrophosphatase (2001), Biochim. Biophys. Acta, 1526, 86-94.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| F- | - |
Homo sapiens |  |
| N-acetyl-p-benzoquinoneimine | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0004 | - |
ADPribose | pH 7.5, 37°C | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | maximal activity at 2 mM, Mg2+ or Mn2+ required | Homo sapiens | |
| Mn2+ | maximal activity at 0.02-0.05 mM with a steep decrease at increasing pH-values, Mg2+ or Mn2+ required | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP-ribose + H2O | Homo sapiens | the enzyme may have a predominant role in free ADP-ribose turnover and as a protective agent preventing the accumulation of this potential dangerous metabolite | AMP + D-ribose 5-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP-ribose + H2O | - |
Homo sapiens | AMP + D-ribose 5-phosphate | - |
? | |
| ADP-ribose + H2O | the enzyme may have a predominant role in free ADP-ribose turnover and as a protective agent preventing the accumulation of this potential dangerous metabolite | Homo sapiens | AMP + D-ribose 5-phosphate | - |
? | |
| IDP-ribose + H2O | 138% of the activity with ADPribose | Homo sapiens | IMP + D-ribose 5-phosphate | - |
? | |
| additional information | no activity with ADPglucose, ADPmannose, UDPglucose | Homo sapiens | ? | - |
? | |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 9 | linearly decreasing activity profile from pH 7 to pH 9, with activity at pH 9 being 50% of that at pH 7 | Homo sapiens |
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Release 2023.1 (January 2023)
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