Organism | UniProt | Comment | Textmining |
---|---|---|---|
Campylobacter jejuni | A0A0H3PAT6 | - |
- |
Campylobacter jejuni | A0A0H3PES2 | - |
- |
Campylobacter jejuni 81-176 | A0A0H3PAT6 | - |
- |
Campylobacter jejuni 81-176 | A0A0H3PES2 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
CJJ81176_0377 | - |
Campylobacter jejuni |
CJJ81176_1251 | - |
Campylobacter jejuni |
PPX1 | - |
Campylobacter jejuni |
General Information | Comment | Organism |
---|---|---|
physiological function | deletion mutants of exopolyphosphatases Ppx1, Ppx2 and the double knockout mutant all exhibit increased capacity to accumulate polyphosphate. Ppx1 and double mutants show decreased accumulation of ppGpp, an alarmone molecule. The lack of ppx gene products results in defects in motility, biofilm formation, nutrient stress survival, invasion and intracellular survival indicating that maintaining a certain level of polyphosphate is critical for Ppx genes in Campylobacter jejuni pathophysiology. Both Ppx1 and Ppx2 mutants are resistant to human complement-mediated killing. The double mutant mutant is sensitive. The serum susceptibility does not occur in the presence of MgCl2 and EGTA. The chicken serum does not have any effect on the mutants' survival. The observed serum susceptibility is not related to surface capsule and lipooligosaccharide structures | Campylobacter jejuni |
physiological function | double deletion mutants of exopolyphosphatases Ppx1/Ppx2 and the double knockout mutant all exhibit increased capacity to accumulate polyphosphate. Ppx1 and double mutants show decreased accumulation of ppGpp, an alarmone molecule. The lack of ppx gene products results in defects in motility, biofilm formation, nutrient stress survival, invasion and intracellular survival indicating that maintaining a certain level of polyphosphate is critical for Ppx genes in Campylobacter jejuni pathophysiology. Both Ppx1 and Ppx2 mutants are resistant to human complement-mediated killing. The double mutant mutant is sensitive. The serum susceptibility does not occur in the presence of MgCl2 and EGTA. The chicken serum does not have any effect on the mutants' survival. The observed serum susceptibility is not related to surface capsule and lipooligosaccharide structures | Campylobacter jejuni |