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Literature summary for 3.6.1.1 extracted from

  • Mirra, B.; Carvalho, K.; Curitiba, B.; Ribeiro, L.; Moraes, J.; da Silva, J.R.; Costa, E.P.; da Fonseca, R.N.; Campos, E.
    Inorganic pyrophosphatase from the red flour beetle (Tribolium castaneum) modulates mitochondrial polyphosphate metabolism (2019), Arch. Insect Biochem. Physiol., 102, e21606 .
    View publication on PubMed
Search for more literature for 3.6.1.1

Cloned(Commentary)

Cloned (Comment) Organism
gene TcasGA2_TC004566, real-time PCR expression analysis Tribolium castaneum

Protein Variants

Protein Variants Comment Organism
additional information knockdown of Tc-SPPase in the genome of Tribolium castaneum via pRNAi. Injection of Tc-sPPase dsRNA completely inhibits its expression when compared to the control, confirming that Tc-sPPase transcription is largely reduced Tribolium castaneum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Tribolium castaneum 5739
-
soluble
-
 Tribolium castaneum
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Tribolium castaneum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
diphosphate + H2O Tribolium castaneum
-
 2 phosphate
-
 ?
triphosphate + H2O Tribolium castaneum
-
 3 phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Tribolium castaneum D6WB60
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diphosphate + H2O
-
 Tribolium castaneum 2 phosphate
-
 ?
triphosphate + H2O
-
 Tribolium castaneum 3 phosphate
-
 ?

Synonyms

Synonyms Comment Organism
inorganic pyrophosphatase
-
 Tribolium castaneum
inorganic pyrophosphatase-like protein UniProt Tribolium castaneum
PPase
-
 Tribolium castaneum
soluble inorganic pyrophosphatase
-
 Tribolium castaneum
Tc-sPPase
-
 Tribolium castaneum
TC004566
-
 Tribolium castaneum
TcasGA2_TC004566 locus name Tribolium castaneum

General Information

General Information Comment Organism
malfunction tripolyphosphate is able to increase the F-ATPase activity in wild-type and Tc-sPPase RNAi beetles. sPPase gene knock-down influences polyP metabolism in mitochondria, mainly tripolyphosphate metabolism Tribolium castaneum
metabolism inorganic pyrophosphatase modulates polyphosphate metabolism in mitochondria and affects the link between mitochondrial activity and polyphosphate metabolism in Tibolium castaneum. Mitochondrial respiration modulates exopolyphosphatase activity (EC 3.6.1.11) only in wild-type beetles. The soluble form has a greater affinity for polyP3, and the membrane form has a greater affinity for polyP15, with only the soluble PPX activity being affected by Tc-sPPase RNAi Tribolium castaneum
physiological function presence of two exopolyphosphatase isoforms in mitochondria. Tribolium castaneum mitochondrial polyP levels decrease after injection with soluble diphosphatase (Tc-sPPase) dsRNA, while the membrane exopolyphosphate activity (EC 3.6.1.11) increases Tribolium castaneum