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Literature summary for 3.5.99.6 extracted from
- Glucosamine 6-phosphate deaminase in normal human erythrocytes (1995), Br. J. Haematol., 91, 72-79.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| N-acetylgalactosamine | - |
Homo sapiens |  |
| N-acetylglucosamine | - |
Homo sapiens | |
| UDP-N-acetylglucosamine | slight activation at 0.00167-0.167 mM, slight inhibition at 1.67 mM | Homo sapiens | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | - |
Homo sapiens | |
| D-fructose 1,6-diphosphate | - |
Homo sapiens | |
| D-fructose 6-phosphate | - |
Homo sapiens | |
| D-glucose 6-phosphate | - |
Homo sapiens | |
| EDTA | no inhibition | Homo sapiens | |
| N-acetylglucosamine 6-phosphate | - |
Homo sapiens | |
| Ni2+ | - |
Homo sapiens | |
| UDP-N-acetylglucosamine | slight inhibition at 1.67 mM, slight activation at 0.00167-0.167 mM | Homo sapiens | |
| Zn2+ | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.041 | - |
D-glucosamine 6-phosphate | pH 9, 37°C | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the activity of the enzyme in erythrocytes is low, indicating that hexosamine catabolism is not a major source of energy in the erythrocyte | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucosamine 6-phosphate + H2O | - |
Homo sapiens | D-fructose 6-phosphate + NH3 | - |
? | |
| additional information | the activity of the enzyme in erythrocytes is low, indicating that hexosamine catabolism is not a major source of energy in the erythrocyte | Homo sapiens | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Homo sapiens |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 32 | 47 | about 90% of maximal activity at 32°C and 47°C | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
- |
Homo sapiens |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | chromatofocusing | - |
8.55 |
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