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Literature summary for 3.5.99.5 extracted from
- Tryptophan catabolism: Identification and characterization of a new degradative pathway (2005), J. Bacteriol., 187, 7866-7869.
Application
| Application | Comment | Organism |
|---|---|---|
| degradation | new tryptophan catabolic pathway in Burholderia cepacia J2315, formation of the intermediate 4-oxalocrotonate differentiates this pathway from the proposed mammalian pathway which converts 2-aminomuconate to 2-ketoadipate and, ultimately, glutaryl-coenzyme A | Burkholderia cepacia |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cloned into plasmid pDESTF1 and overexpressed in Escherichia coli Tuner (DE3) | Burkholderia cepacia |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 18000 | - |
overexpressed soluble protein | Burkholderia cepacia |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Burkholderia cepacia | - |
- |
- |
| Burkholderia cepacia J2315 | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| by nickel-nitrilotriacetic acid affinity chromatography | Burkholderia cepacia |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-aminomuconate + H2O | - |
Burkholderia cepacia | 4-oxalocrotonate + NH3 | - |
? |  |
| 2-aminomuconate + H2O | - |
Burkholderia cepacia J2315 | 4-oxalocrotonate + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 2-aminomuconate deaminase | - |
Burkholderia cepacia |
| AMD | - |
Burkholderia cepacia |
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