Literature summary for extracted from

  • Bergeron, S.; Chaplin, D.A.; Edwards, J.H.; Ellis, B.S.; Hill, C.L.; Holt-Tiffin, K.; Knight, J.R.; Mahoney, T.; Osborne, A.P.; Ruecroft, G.
    Nitrilase-catalyzed desymmetrization of 3-hydroxyglutaronitrile: preparation of a statin side-chain intermediate (2006), Org. Proc. Res. Dev., 10, 661-665.
No PubMed abstract available


Application Comment Organism
synthesis an efficient, scaleable synthesis of ethyl (R)-4-cyano-3-hydroxybutyrate, a potential intermediate in the synthesis of Atorvastatin (Lipitor) involves nitrilase-catalyzed desymmetrization of 3-hydroxyglutaronitrile Pseudomonas fluorescens


Organism UniProt Comment Textmining
Pseudomonas fluorescens