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Literature summary for 3.5.5.1 extracted from

  • Brady, D.; Beeton, A.; Zeevaart, J.; Kgaje, C.; van Rantwijk, F.; Sheldon, R.A.
    Characterisation of nitrilase and nitrile hydratase biocatalytic systems (2004), Appl. Microbiol. Biotechnol., 64, 76-85.
    View publication on PubMed

Application

Application Comment Organism
synthesis enzyme can be used as a biocatalyst for the synthesis of a range of alpha-hydroxy carboxylic acids or amides from aldehydes in presence of cyanide, halting of the reaction at the amide intermediate by use of specific inhibitors is possible Rhodococcus sp.

Inhibitors

Inhibitors Comment Organism Structure
additional information
-
Rhodococcus sp.

Organism

Organism UniProt Comment Textmining
Rhodococcus sp.
-
-
-

Reaction

Reaction Comment Organism Reaction ID
a nitrile + 2 H2O = a carboxylate + NH3 acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile, and also on some aliphatic nitriles, and on the corresponding acid amines Rhodococcus sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-3-phenylpropionitrile + H2O beta-substituted substrate Rhodococcus sp. 3-hydroxy-3-phenylpropionic acid + NH3
-
?
3-hydroxy-3-phenylpropionitrile + H2O beta-substituted substrate Rhodococcus sp. Novo SP361 3-hydroxy-3-phenylpropionic acid + NH3
-
?
additional information substrate specificity profile, enzyme also catalyzes the synthesis of a range of alpha-hydroxy carboxylic acids or amides from aldehydes in presence of cyanide Rhodococcus sp. ?
-
?
additional information substrate specificity profile, enzyme also catalyzes the synthesis of a range of alpha-hydroxy carboxylic acids or amides from aldehydes in presence of cyanide Rhodococcus sp. Novo SP361 ?
-
?

Synonyms

Synonyms Comment Organism
nitrile hydratase/amidase
-
Rhodococcus sp.