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Literature summary for 3.5.5.1 extracted from

  • Almatawah, Q.A.; Cramp, R.; Cowan, D.A.
    Characterization of an inducible nitrilase from a thermophilic bacillus (1999), Extremophiles, 3, 283-291.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
L-cystine 16% activation at 1 mM Aeribacillus pallidus
NaHS 19% activation at 1 mM Aeribacillus pallidus

Inhibitors

Inhibitors Comment Organism Structure
4,7-phenanthroline 34% inhibition at 1 mM Aeribacillus pallidus
4-chloromercuribenzoate complete inhibition at 1 mM Aeribacillus pallidus
4-hydroxymercuribenzoic acid strong inhibition at 1 mM Aeribacillus pallidus
5,5'-dithiobis(2-nitrobenzoic acid) 45% inhibition at 1 mM Aeribacillus pallidus
8-hydroxyquinoline 36% inhibition at 1 mM Aeribacillus pallidus
Ag+ strong inhibition at 1 mM Aeribacillus pallidus
dithiothreitol slight inhibition at 1 mM Aeribacillus pallidus
Fe2+ slight inhibition at 1 mM Aeribacillus pallidus
GSH slight inhibition at 1 mM Aeribacillus pallidus
Hg2+ strong inhibition at 1 mM Aeribacillus pallidus
iodoacetamide slight inhibition at 1 mM Aeribacillus pallidus
iodoacetic acid slight inhibition at 1 mM Aeribacillus pallidus
phenylhydrazine slight inhibition at 1 mM Aeribacillus pallidus
Phenylmercuriacetate complete inhibition at 1 mM Aeribacillus pallidus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.086
-
3-chlorobenzonitrile
-
Aeribacillus pallidus
0.3
-
2-Cyanopyridine
-
Aeribacillus pallidus
0.92
-
Benzonitrile
-
Aeribacillus pallidus
1.3
-
4-chlorobenzonitrile
-
Aeribacillus pallidus
2.7
-
3-Cyanopyridine
-
Aeribacillus pallidus
22.5
-
4-cyanopyridine
-
Aeribacillus pallidus
41
-
4-Chlorobutyronitrile
-
Aeribacillus pallidus
124
-
Crotononitrile
-
Aeribacillus pallidus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-cyanopyridine + 2 H2O Aeribacillus pallidus
-
nicotinic acid + NH3
-
?
benzonitrile + 2 H2O Aeribacillus pallidus
-
benzoic acid + NH3
-
?

Organism

Organism UniProt Comment Textmining
Aeribacillus pallidus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
near homogeneity, chromatography techniques Aeribacillus pallidus

Source Tissue

Source Tissue Comment Organism Textmining
cell culture best inducer of enzyme formation: benzonitrile Aeribacillus pallidus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-cyanopyridine + 2 H2O
-
Aeribacillus pallidus 2-pyridine carboxylic acid + NH3
-
?
2-fluorobenzonitrile + H2O
-
Aeribacillus pallidus 2-fluorobenzoic acid + NH3
-
?
2-toluonitrile + H2O
-
Aeribacillus pallidus NH3 + 2-methylbenzoate
-
?
3-aminobenzonitrile + H2O
-
Aeribacillus pallidus 3-aminobenzoic acid + NH3
-
?
3-chloro-4-fluorobenzonitrile + H2O
-
Aeribacillus pallidus 3-chloro-4-fluorobenzoic acid + NH3
-
?
3-chlorobenzonitrile + H2O
-
Aeribacillus pallidus 3-chlorobenzoic acid + NH3
-
?
3-cyanopyridine + 2 H2O
-
Aeribacillus pallidus nicotinic acid + NH3
-
?
3-fluorobenzonitrile + H2O
-
Aeribacillus pallidus 3-fluorobenzoic acid + NH3
-
?
3-hydroxybenzonitrile + H2O
-
Aeribacillus pallidus 3-hydroxybenzoic acid + NH3
-
?
3-nitrobenzonitrile + H2O
-
Aeribacillus pallidus 3-nitrobenzoic acid + NH3
-
?
3-toluonitrile + H2O
-
Aeribacillus pallidus NH3 + 3-methylbenzoate
-
?
4-chlorobenzonitrile + H2O
-
Aeribacillus pallidus 4-chlorobenzoic acid + NH3
-
?
4-chlorobutyronitrile + H2O
-
Aeribacillus pallidus 4-chlorobutyric acid + NH3
-
?
4-cyanopyridine + 2 H2O best substrate Aeribacillus pallidus 4-pyridinecarboxylic acid + NH3
-
?
4-fluorobenzonitrile + H2O
-
Aeribacillus pallidus 4-fluorobenzoic acid + NH3
-
?
4-hydroxybenzonitrile + H2O
-
Aeribacillus pallidus 4-hydroxybenzoic acid + NH3
-
?
4-nitrobenzonitrile + H2O
-
Aeribacillus pallidus 4-nitrobenzoic acid + NH3
-
?
4-toluonitrile + H2O
-
Aeribacillus pallidus NH3 + 4-methylbenzoate
-
?
allylcyanide + H2O
-
Aeribacillus pallidus NH3 + but-3-enoic acid
-
?
benzonitrile + 2 H2O
-
Aeribacillus pallidus benzoic acid + NH3
-
?
crotononitrile + H2O
-
Aeribacillus pallidus NH3 + (z)-but-2-en-1-ol
-
?
n-butyronitrile + H2O
-
Aeribacillus pallidus n-butyric acid + NH3
-
?
n-valeronitrile + H2O
-
Aeribacillus pallidus n-valeric acid + NH3
-
?
trans-3-pentenenitrile + H2O
-
Aeribacillus pallidus trans-3-pentenoic acid + NH3
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
65
-
-
Aeribacillus pallidus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
70
-
rapid inactivation above Aeribacillus pallidus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1370
-
3-chlorobenzonitrile
-
Aeribacillus pallidus
11100
-
4-Chlorobutyronitrile
-
Aeribacillus pallidus
14400
-
Benzonitrile
-
Aeribacillus pallidus
43900
-
4-cyanopyridine
-
Aeribacillus pallidus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
-
Aeribacillus pallidus

pH Range

pH Minimum pH Maximum Comment Organism
6 9 constant activity within Aeribacillus pallidus