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Literature summary for 3.5.4.B9 extracted from

  • Monajemi, M.; Woodworth, C.F.; Benkaroun, J.; Grant, M.; Larijani, M.
    Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment (2012), Retrovirology, 9, 35.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.B9

Inhibitors

Inhibitors Comment Organism Structure
additional information the virion infectivity factor of HIV binds cytoplasmic enzyme marking it for degradation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxycytosine in single-stranded viral DNA + H2O Homo sapiens
-
 deoxyuridine in single-stranded viral DNA + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HC16
-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:CD4+ cell
-
 Homo sapiens
-
monocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxycytosine in single-stranded viral DNA + H2O
-
 Homo sapiens deoxyuridine in single-stranded viral DNA + NH3
-
 ?

Synonyms

Synonyms Comment Organism
A3G
-
 Homo sapiens
APOBEC3G
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme mutates the human immunodeficiency virus (HIV) genome by converting deoxycytidine to deoxyuridine in signature trinucleotides (CCC, TCC) on minus strand viral DNA during reverse transcription. The enzyme restricts viral propagation by degrading or incapacitating the coding ability of the HIV genome. The enzyme contributes to the evasion of adaptive immunity by HIV Homo sapiens