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Literature summary for 3.5.4.B9 extracted from
- The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA (2003), Nature, 424, 94-98.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| glutathione S-transferase-tagged enzyme is expressed in Escherichia coli | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C288A/C291A | the mutant enzyme shows about 18% activity compared to the wild type enzyme | Homo sapiens |
| C97A/C100A | the mutant enzyme shows about 18% activity compared to the wild type enzyme | Homo sapiens |
| H257A | the mutant enzyme shows about 10% activity compared to the wild type enzyme | Homo sapiens |
| H81A | the mutant enzyme shows about 25% activity compared to the wild type enzyme | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | contains two zinc finger domains | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytosine in single-stranded viral DNA + H2O | Homo sapiens | - |
uracil in single-stranded viral DNA + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293T cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytosine in single-stranded viral DNA + H2O | - |
Homo sapiens | uracil in single-stranded viral DNA + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| APOBEC3G | - |
Homo sapiens |
| apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | - |
Homo sapiens |
| CEM15 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is an endogenous inhibitor of human immunodeficiency virus type 1 (HIV-1) replication, able to induce G to A hypermutation in newly synthesized viral DNA | Homo sapiens |
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