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Literature summary for 3.5.4.6 extracted from

  • Lee, S.; Wang, Y.; Kim, S.O.; Han, J.
    AMPD3 is involved in anthrax LeTx-induced macrophage cell death (2011), Protein Cell, 2, 564-572.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information AMP deaminase 3 is mutated in one of the mutant clones resistant to anthrax lethal toxin-induced death, restoration of anthrax lethal toxin sensitivity with ectopic reconstitution of AMPD3 expression Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
AMP + H2O Mus musculus
-
IMP + NH3
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
RAW-264.7 cell a macrophage-like cell line sensitive to anthrax lethal toxin, i.e. LeTx, induced death Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
AMP + H2O
-
Mus musculus IMP + NH3
-
?

Synonyms

Synonyms Comment Organism
AMP deaminase 3
-
Mus musculus
AMPD3
-
Mus musculus

General Information

General Information Comment Organism
malfunction AMP deaminase 3 is mutated in one of the mutant clones resistant to anthrax lethal toxin-induced death, AMPD3 deficiency does not affect anthrax lethal toxin entering cells and the cleavage of mitogen-activated protein kinase kinase by lethal factor inside cells, but does impair a downstream event that is linked to cell death. Restoration of anthrax lethal toxin sensitivity with ectopic reconstitution of AMPD3 expression Mus musculus
physiological function requirement of AMPD3 in anthrax lethal toxin-induced cell death of RAW 264.7 cells Mus musculus