Protein Variants | Comment | Organism |
---|---|---|
additional information | AMP deaminase 3 is mutated in one of the mutant clones resistant to anthrax lethal toxin-induced death, restoration of anthrax lethal toxin sensitivity with ectopic reconstitution of AMPD3 expression | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
AMP + H2O | Mus musculus | - |
IMP + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
RAW-264.7 cell | a macrophage-like cell line sensitive to anthrax lethal toxin, i.e. LeTx, induced death | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
AMP + H2O | - |
Mus musculus | IMP + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AMP deaminase 3 | - |
Mus musculus |
AMPD3 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | AMP deaminase 3 is mutated in one of the mutant clones resistant to anthrax lethal toxin-induced death, AMPD3 deficiency does not affect anthrax lethal toxin entering cells and the cleavage of mitogen-activated protein kinase kinase by lethal factor inside cells, but does impair a downstream event that is linked to cell death. Restoration of anthrax lethal toxin sensitivity with ectopic reconstitution of AMPD3 expression | Mus musculus |
physiological function | requirement of AMPD3 in anthrax lethal toxin-induced cell death of RAW 264.7 cells | Mus musculus |