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Literature summary for 3.5.4.6 extracted from
- Synthesis and biochemical testing of 3-(carboxyphenylethyl)imidazo[2,1-f] [1,2,4]triazines as inhibitors of AMP deaminase (2010), ACS Med. Chem. Lett., 1, 286-289.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-bromo-4-[2-(8-hydroxy-7,8-dihydroimidazo[4,5-d][1,3]diazepin-3(6H)-yl)ethyl]-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid | - |
Arabidopsis thaliana |  |
| 1-bromo-4-[2-(8-hydroxy-7,8-dihydroimidazo[4,5-d][1,3]diazepin-3(6H)-yl)ethyl]-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid | - |
Homo sapiens | |
| 3-[2-(3-carboxy-5,6,7,8-tetrahydronaphthyl)-ethyl]imidazo[2,1-f][1,2,4]triazine | - |
Arabidopsis thaliana | |
| 3-[2-(3-carboxy-5,6,7,8-tetrahydronaphthyl)-ethyl]imidazo[2,1-f][1,2,4]triazine | good inhibitor of isozyme AMPD3 | Homo sapiens | |
| 3-[2-(8-hydroxy-7,8-dihydroimidazo[4,5-d][1,3]diazepin-3(6H)-yl)ethyl]benzoic acid | - |
Arabidopsis thaliana | |
| 3-[2-(8-hydroxy-7,8-dihydroimidazo[4,5-d][1,3]diazepin-3(6H)-yl)ethyl]benzoic acid | - |
Homo sapiens | |
| 3-[2-(imidazo[2,1-f][1,2,4]triazin-7-yl)ethyl]benzoic acid | - |
Arabidopsis thaliana | |
| 3-[2-(imidazo[2,1-f][1,2,4]triazin-7-yl)ethyl]benzoic acid | - |
Homo sapiens | |
| 4-[2-(8-hydroxy-7,8-dihydroimidazo[4,5-d][1,3]diazepin-3(6H)-yl)ethyl]-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid | - |
Arabidopsis thaliana | |
| 4-[2-(8-hydroxy-7,8-dihydroimidazo[4,5-d][1,3]diazepin-3(6H)-yl)ethyl]-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid | - |
Homo sapiens | |
| coformycin 5'-phosphate | extremely potent AMPD inhibitor | Arabidopsis thaliana | |
| coformycin 5'-phosphate | extremely potent AMPD inhibitor | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| AMP + H2O | - |
Homo sapiens | IMP + NH3 | - |
? | |
| AMP + H2O | - |
Arabidopsis thaliana | IMP + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AmpD | - |
Arabidopsis thaliana |
| AMPD1 | isozyme | Homo sapiens |
| AMPD2 | isozyme | Homo sapiens |
| AMPD3 | isozyme | Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0009 | - |
isozyme AMPD3, pH and temperature not specified in the publication | Homo sapiens | 3-[2-(3-carboxy-5,6,7,8-tetrahydronaphthyl)-ethyl]imidazo[2,1-f][1,2,4]triazine | |
| 0.0023 | - |
isozyme AMPD2, pH and temperature not specified in the publication | Homo sapiens | 3-[2-(3-carboxy-5,6,7,8-tetrahydronaphthyl)-ethyl]imidazo[2,1-f][1,2,4]triazine | |
| 0.0057 | - |
isozyme AMPD1, pH and temperature not specified in the publication | Homo sapiens | 3-[2-(3-carboxy-5,6,7,8-tetrahydronaphthyl)-ethyl]imidazo[2,1-f][1,2,4]triazine | |
| 0.1 | - |
isozyme AMPD2, pH and temperature not specified in the publication | Homo sapiens | 3-[2-(imidazo[2,1-f][1,2,4]triazin-7-yl)ethyl]benzoic acid | |
| 0.2 | - |
pH and temperature not specified in the publication | Arabidopsis thaliana | 3-[2-(3-carboxy-5,6,7,8-tetrahydronaphthyl)-ethyl]imidazo[2,1-f][1,2,4]triazine | |
| 0.31 | - |
isozyme AMPD1, pH and temperature not specified in the publication | Homo sapiens | 3-[2-(imidazo[2,1-f][1,2,4]triazin-7-yl)ethyl]benzoic acid | |
| 0.37 | - |
isozyme AMPD3, pH and temperature not specified in the publication | Homo sapiens | 3-[2-(imidazo[2,1-f][1,2,4]triazin-7-yl)ethyl]benzoic acid | |
| 1.4 | - |
pH and temperature not specified in the publication | Arabidopsis thaliana | 3-[2-(imidazo[2,1-f][1,2,4]triazin-7-yl)ethyl]benzoic acid | |
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