Literature summary for 3.5.4.5 extracted from

Sanchez-Quitian, Z.A.; Timmers, L.F.; Caceres, R.A.; Rehm, J.G.; Thompson, C.E.; Basso, L.A.; de Azevedo, W.F.; Santos, D.S.
Crystal structure determination and dynamic studies of Mycobacterium tuberculosis cytidine deaminase in complex with products (2011), Arch. Biochem. Biophys., 509, 108-115.

Application

Application	Comment	Organism
drug development	CDA is a target for development of specific enzyme inhibitors with potential anti-proliferative activity on cell growth of Mycobacterium tuberculosis, the major causative agent of tuberculosis	Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment)	Organism
purified CDA in complex with uridine and deoxyuridine, hanging drop vapor diffusion method, 0.002 ml of 12 mg/ml protein in 20 mM Tris-HCl pH 7.5 is mixed with 0.002 ml of reservoir solution containing 0.1 M HEPES, pH 7.5 and 4.3 M sodium chloride, ligands uridine and deoxyuridine are added by soaking method, X-ray diffractiuon structure determination and analysis at 2.4 and 1.9 A resolution,molecular dynamics simulation, structure modeling	Mycobacterium tuberculosis

Crystallization (Comment)

Organism

purified CDA in complex with uridine and deoxyuridine, hanging drop vapor diffusion method, 0.002 ml of 12 mg/ml protein in 20 mM Tris-HCl pH 7.5 is mixed with 0.002 ml of reservoir solution containing 0.1 M HEPES, pH 7.5 and 4.3 M sodium chloride, ligands uridine and deoxyuridine are added by soaking method, X-ray diffractiuon structure determination and analysis at 2.4 and 1.9 A resolution,molecular dynamics simulation, structure modeling

Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WPH3	-	-
Mycobacterium tuberculosis H37Rv	P9WPH3	-	-

Subunits

Subunits	Comment	Organism
tetramer	-	Mycobacterium tuberculosis

Synonyms

Synonyms	Comment	Organism
CDA	-	Mycobacterium tuberculosis

General Information

General Information	Comment	Organism
metabolism	cytidine deaminase is a key enzyme in the pyrimidine salvage pathway	Mycobacterium tuberculosis
physiological function	cytidine amidase is involved in the hydrolytic deamination of cytidine or 2'-deoxycytidine to uridine or 2'-deoxyuridine, determination of the protein-ligand recognition process, respectively	Mycobacterium tuberculosis