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Literature summary for 3.5.4.4 extracted from

  • Zimmermann, S.C.; Sadler, J.M.; ODaniel, P.I.; Kim, N.T.; Seley-Radtke, K.L.
    Reverse carbocyclic fleximers: synthesis of a new class of adenosine deaminase inhibitors (2013), Nucleosides Nucleotides Nucleic Acids, 32, 137-154.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.4

Inhibitors

Inhibitors Comment Organism Structure
1-[(2S,3R)-2,3-dihydroxycyclopentyl]-5-(1,3-thiazol-5-yl)pyrimidine-2,4(1H,3H)-dione 28% inhibition at 0.1 mM Bos taurus
1-[(2S,3R)-2,3-dihydroxycyclopentyl]-5-(furan-2-yl)pyrimidine-2,4(1H,3H)-dione 35% inhibition at 0.1 mM Bos taurus
1-[(2S,3R)-2,3-dihydroxycyclopentyl]-5-(thiophen-2-yl)pyrimidine-2,4(1H,3H)-dione 36% inhibition at 0.1 mM Bos taurus
1-[(4R,5S)-4,5-dihydroxycyclopent-2-en-1-yl]-5-(1,3-thiazol-5-yl)pyrimidine-2,4(1H,3H)-dione 49% inhibition at 0.1 mM Bos taurus
1-[(4R,5S)-4,5-dihydroxycyclopent-2-en-1-yl]-5-(furan-2-yl)pyrimidine-2,4(1H,3H)-dione 55% inhibition at 0.1 mM Bos taurus
1-[(4R,5S)-4,5-dihydroxycyclopent-2-en-1-yl]-5-(thiophen-2-yl)pyrimidine-2,4(1H,3H)-dione 48% inhibition at 0.1 mM Bos taurus
Inosine 31% inhibition at 0.1 mM Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
adenosine + H2O Bos taurus
-
 inosine + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus P56658
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine + H2O
-
 Bos taurus inosine + NH3
-
 ?

Synonyms

Synonyms Comment Organism
ADA
-
 Bos taurus