Application | Comment | Organism |
---|---|---|
drug development | enzyme inhibitor FR234938 might be effective as an anti-rheumatic and anti-inflammatory drug by modulating the host-defense concentrations of adenosine | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
enzyme expression in an enzyme-deficient Escherichia coli strain Sphi3834 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
FR234938 | i.e. 1-((1R,2S)-2-hydroxy-1-(2-(1-naphthyl)ethyl)propyl)1H-imidazole-4-carboxamine, a non-nucleoside inhibitor, the inhibition is blocked by an A2a adenosine receptor antagonist | Homo sapiens | |
pentostatin | i.e. (8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-deoxyadenosine + H2O | Homo sapiens | - |
2'-deoxyinosine + NH3 | - |
ir | |
adenosine + H2O | Homo sapiens | metabolization of extracellular adenosine leads to exacerbation of inflammation | inosine + NH3 | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SKW6.4 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-deoxyadenosine + H2O | - |
Homo sapiens | 2'-deoxyinosine + NH3 | - |
ir | |
adenosine + H2O | metabolization of extracellular adenosine leads to exacerbation of inflammation | Homo sapiens | inosine + NH3 | - |
ir | |
adenosine + H2O | metabolization of extracellular adenosine | Homo sapiens | inosine + NH3 | - |
ir |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000027 | - |
pH 7.4, 22°C | Homo sapiens | FR234938 |