Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-deoxycoformycin | 0.0015 nM, 50% inhibition | Gallus gallus | |
2'-deoxycoformycin | 0.0004 nM, 50% inhibition | Homo sapiens | |
erythro-9-(2-hydroxy-3-nonyl)-adenine hydrochloride | 0.4 nM, 50% inhibition | Gallus gallus | |
erythro-9-(2-hydroxy-3-nonyl)-adenine hydrochloride | 0.45 nM, 50% inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000023 | - |
adenosine | - |
Gallus gallus | |
0.000046 | - |
adenosine | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
a second band of 300000 Da is detected for the complex of adenosine deaminase 1 with dipeptidyl peptidase IV, non-denaturing PAGE | Homo sapiens |
42000 | - |
1 * 42000, enzyme exists as monomer, not in complex with dipeptidyl peptidase IV, SDS-PAGE | Gallus gallus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Gallus gallus |
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Gallus gallus | - |
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
20 | - |
- |
Gallus gallus |
28.49 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2',3'-deoxyadenosine + H2O | 1.7% of the activity with adenosine | Gallus gallus | 2',3'-deoxyinosine + NH3 | - |
? | |
2'-deoxyadenosine + H2O | 79.2% of the activity with adenosine | Gallus gallus | 2'-deoxyinosine + NH3 | - |
? | |
2'-deoxyadenosine + H2O | 82.8% of the activity with adenosine | Homo sapiens | 2'-deoxyinosine + NH3 | - |
? | |
3'-deoxyadenosine + H2O | 2.4% of the activity with adenosine | Gallus gallus | 3'-deoxyinosine + NH3 | - |
? | |
adenosine + H2O | - |
Gallus gallus | inosine + NH3 | - |
? | |
adenosine + H2O | - |
Homo sapiens | inosine + NH3 | - |
? | |
additional information | activity with 3'-deoxyadenosine, 2',3'-deoxyadenosine and 2'-O-methyladenosine is less than 0.5% of the activity with adenine | Homo sapiens | ? | - |
? | |
additional information | no activity with 2'-O-methyladenosine | Gallus gallus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 42000, enzyme exists as monomer, not in complex with dipeptidyl peptidase IV, SDS-PAGE | Gallus gallus |
monomer | 1 * 42000, in human liver the adenosine deaminase 1 mainly exists as a complex with dipeptidyl peptidase IV. The molar ratio of adenosine deaminase 1 to dipeptidyl peptidase IV appears to be 2:1, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ADA1 | - |
Gallus gallus |
ADA1 | - |
Homo sapiens |
adenosine deaminase 1 | - |
Gallus gallus |
adenosine deaminase 1 | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8 | - |
Gallus gallus |
7.5 | 8 | - |
Homo sapiens |