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Literature summary for 3.5.4.4 extracted from

  • Jun, H.K.; Yeeh, Y.
    Purification and charaterization of an extracellular adenosine deaminase from Nocardioides sp. J-326TK (1994), Biotechnol. Appl. Biochem., 20, 265-277.
    View publication on PubMed
Search for more literature for 3.5.4.4

Application

Application Comment Organism
medicine therapy for adenosine-deficient patients with combined immunodeficiency Nocardioides sp.

Inhibitors

Inhibitors Comment Organism Structure
8-Bromoadenosine
-
 Nocardioides sp.
Ag2+
-
 Nocardioides sp.
Cd2+
-
 Nocardioides sp.
Hg2+
-
 Nocardioides sp.
Mg2+
-
 Nocardioides sp.
Mn2+
-
 Nocardioides sp.
o-phenanthroline
-
 Nocardioides sp.
Pentachlorophenol
-
 Nocardioides sp.
Theobromine
-
 Nocardioides sp.
theophylline
-
 Nocardioides sp.
Zn2+
-
 Nocardioides sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.2
-
 2'-deoxyadenosine
-
 Nocardioides sp.
0.22
-
 adenosine
-
 Nocardioides sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Nocardioides sp.
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe3+
-
 Nocardioides sp.
Sn2+
-
 Nocardioides sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
72000
-
 SDS-PAGE Nocardioides sp.
80000
-
 gel filtration Nocardioides sp.

Organism

Organism UniProt Comment Textmining
Nocardioides sp.
-
 J-326TK
-
Nocardioides sp. J-326TK
-
 J-326TK
-

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4677
-
-
 Nocardioides sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2',3'-isopropylideneadenosine + H2O
-
 Nocardioides sp. 2',3'-isopropylideneinosine + NH3
-
 ir
2',3'-isopropylideneadenosine + H2O
-
 Nocardioides sp. J-326TK 2',3'-isopropylideneinosine + NH3
-
 ir
2'-deoxyadenosine + H2O
-
 Nocardioides sp. 2'-deoxyinosine + NH3
-
 ir
2'-deoxyadenosine + H2O
-
 Nocardioides sp. J-326TK 2'-deoxyinosine + NH3
-
 ir
5'-AMP + H2O
-
 Nocardioides sp. 5'-IMP + NH3
-
 ir
5'-AMP + H2O
-
 Nocardioides sp. J-326TK 5'-IMP + NH3
-
 ir
adenosine + H2O
-
 Nocardioides sp. inosine + NH3
-
 ir
adenosine + H2O
-
 Nocardioides sp. J-326TK inosine + NH3
-
 ir
adenosine-3'-monophosphate + H2O
-
 Nocardioides sp. IMP-3'-monophosphate + NH3
-
 ir
ADP + H2O
-
 Nocardioides sp. 5'-IDP + NH3
-
 ir
ADP + H2O
-
 Nocardioides sp. J-326TK 5'-IDP + NH3
-
 ir
ATP + H2O
-
 Nocardioides sp. ITP + NH3
-
 ir

Subunits

Subunits Comment Organism
monomer 72000, SDS-PAGE Nocardioides sp.

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
50
-
-
 Nocardioides sp.

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
20 65
-
 Nocardioides sp.

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
30
-
 30°C and below Nocardioides sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 6.5
-
 Nocardioides sp.

pH Stability

pH Stability pH Stability Maximum Comment Organism
6.5 7.5
-
 Nocardioides sp.