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Literature summary for 3.5.4.4 extracted from
- Human malaria parasite adenosine deaminase (1984), J. Biol. Chem., 259, 1472-1475.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,6-diaminopurine | - |
Homo sapiens |  |
| 2,6-diaminopurine | - |
Plasmodium falciparum | |
| 6-methylamino riboside | - |
Homo sapiens | |
| 6-methylamino riboside | - |
Plasmodium falciparum | |
| 6-Methylmercaptopurine riboside | - |
Homo sapiens | |
| 6-Methylmercaptopurine riboside | - |
Plasmodium falciparum | |
| adenine | - |
Homo sapiens | |
| adenine | - |
Plasmodium falciparum | |
| cordycepin | - |
Homo sapiens | |
| cordycepin | - |
Plasmodium falciparum | |
| Deoxycoformycin | - |
Homo sapiens | |
| erythro-9-(2-hydroxy-3-nonyl)adenine | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.049 | - |
adenosine | - |
Homo sapiens | |
| 0.051 | - |
adenosine | - |
Plasmodium falciparum | |
| 0.053 | - |
2'-deoxyadenosine | - |
Homo sapiens | |
| 0.057 | - |
2'-deoxyadenosine | - |
Plasmodium falciparum | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
normal B-cells and T-cell lines MOLT-4 | - |
| Homo sapiens | - |
RPMI-8402 | - |
| Homo sapiens | - |
CCRF-CEM | - |
| Plasmodium falciparum | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | malaria-infected | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.003 | - |
- |
Plasmodium falciparum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2'-deoxyadenosine + H2O | - |
Homo sapiens | 2'-deoxyinosine + NH3 | - |
? | |
| 2'-deoxyadenosine + H2O | - |
Plasmodium falciparum | 2'-deoxyinosine + NH3 | - |
? | |
| adenosine + H2O | - |
Homo sapiens | inosine + NH3 | - |
? | |
| adenosine + H2O | - |
Plasmodium falciparum | inosine + NH3 | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 8 | - |
Homo sapiens |
| 5 | 8 | - |
Plasmodium falciparum |
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