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Literature summary for 3.5.4.38 extracted from
- Activation-induced cytidine deaminase regulates fibroblast growth factor/extracellular signal-regulated kinases signaling to achieve the naive pluripotent state during reprogramming (2019), Stem Cells, 37, 1003-1017 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9WVE0 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AICDA | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | AICDA-/- induced pluripotent stem cells fail to achieve the naive pluripotent state and remain primed for differentiation because of a failure to suppress fibroblast growth factor FGF/extracellular signal-regulated kinases ERK signaling. The mutant cells display marked genomic hypermethylation, but suppression of FGF/ERK signaling by AICDA is independent of deaminase activity | Mus musculus |
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Release 2023.1 (January 2023)
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