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Literature summary for 3.5.4.38 extracted from

  • Li, X.; Caval, V.; Wain-Hobson, S.; Vartanian, J.P.
    Elephant APOBEC3A cytidine deaminase induces massive double-stranded DNA breaks and apoptosis (2019), Sci. Rep., 9, 728 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in HeLa cell and HEK 293T cell Loxodonta africana

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Loxodonta africana 5737
-
nucleus
-
Loxodonta africana 5634
-

Organism

Organism UniProt Comment Textmining
Loxodonta africana A0A4Y5QRZ7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Loxodonta africana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded DNA + H2O
-
Loxodonta africana uracil in single-stranded DNA + NH3
-
?
additional information enzyme is able to deaminate 5-methylcytosine in DNA Loxodonta africana ?
-
?

Subunits

Subunits Comment Organism
? x * 20900, calculated from sequence Loxodonta africana

Synonyms

Synonyms Comment Organism
APOBEC3A
-
Loxodonta africana
APOBEC3Z1
-
Loxodonta africana

General Information

General Information Comment Organism
physiological function APOBEC3Z1 induces double strand DNA breaks and apoptosis upon expression in HeLa cells Loxodonta africana