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Literature summary for 3.5.4.38 extracted from

  • Marx, A.; Galilee, M.; Alian, A.
    Zinc enhancement of cytidine deaminase activity highlights a potential allosteric role of loop-3 in regulating APOBEC3 enzymes (2015), Sci. Rep., 5, 18191 .
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
G56N mutation at the N-terminus end of loop-3 does not bestow deamination activity Homo sapiens
H248S/H250S increase in the concentration of zinc does not increase deamination activity Homo sapiens
N244A abolishes activity Homo sapiens
N244D abolishes activity Homo sapiens
N244G abolishes activity Homo sapiens
N244L abolishes activity Homo sapiens
N244Q about 3% residual activity Homo sapiens
P210A almost abolishes activity Homo sapiens
P210G almost abolishes activity Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc coordination of a secondary zinc ion enhances deamination activity up to 160%ing is pinpointed to loop-3 which harbors a catalytically essential and spatially conserved asparagine at its N-terminus Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P31941
-
-
Homo sapiens Q9HC16
-
-

Synonyms

Synonyms Comment Organism
APOBEC3G
-
 Homo sapiens