Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.4.38 extracted from

  • Sharma, S.; Patnaik, S.K.; Taggart, R.T.; Kannisto, E.D.; Enriquez, S.M.; Gollnick, P.; Baysal, B.E.
    APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages (2015), Nat. Commun., 6, 6881 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.38

Protein Variants

Protein Variants Comment Organism
C101S mutant lacks bth DNA and RNA deaminase activity Homo sapiens
E72D mutant is moderately impaired in a ssDNA deamination assay but capable of RNA deamination Homo sapiens
P134A about 89% of wild-type RNA deamination activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P31941
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Homo sapiens
-
marrow cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
APOBEC3A
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function APOBEC3A, a is a C>U RNA-editing enzyme that modifies the monocyte/macrophage transcriptome. Transcripts of hundreds of genes undergo sitespecific C>U RNA editing in macrophages during M1 polarization and in monocytes in response to hypoxia and interferons. Amino acid residues of APOBEC3A that are required for its DNA deamination and anti-retrotransposition activities also affect its RNA deamination activity Homo sapiens