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Literature summary for 3.5.4.38 extracted from

  • McBride, K.M.; Gazumyan, A.; Woo, E.M.; Barreto, V.M.; Robbiani, D.F.; Chait, B.T.; Nussenzweig, M.C.
    Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation (2006), Proc. Natl. Acad. Sci. USA, 103, 8798-8803.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
S38A the mutant enzyme shows dimished somatic hypermutation activity on artificial and physiological DNA targets Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded DNA + H2O Mus musculus activation-induced cytidine deaminase (AID) initiates Ig class switch recombination and somatic hypermutation by producing U:G mismatches in DNA. These mismatches also have the potential to induce DNA damage including double-stranded breaks and chromosome translocations uracil in single-stranded DNA + NH3
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Organism

Organism UniProt Comment Textmining
Mus musculus Q9WVE0
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein 5–15% of the enzyme expressed in activated B cells is phosphorylated at Ser38. The modified form contributes disproportionately to hypermutation. This form of activation-induced cytidine deaminase is enriched in the chromatin fraction in activated B cells Mus musculus

Purification (Commentary)

Purification (Comment) Organism
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Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded DNA + H2O
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Mus musculus uracil in single-stranded DNA + NH3
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?
cytosine in single-stranded DNA + H2O activation-induced cytidine deaminase (AID) initiates Ig class switch recombination and somatic hypermutation by producing U:G mismatches in DNA. These mismatches also have the potential to induce DNA damage including double-stranded breaks and chromosome translocations Mus musculus uracil in single-stranded DNA + NH3
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?

Synonyms

Synonyms Comment Organism
activation-induced deaminase
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Mus musculus
AID
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Mus musculus

General Information

General Information Comment Organism
physiological function activation-induced cytidine deaminase (AID) initiates Ig class switch recombination and somatic hypermutation by producing U:G mismatches in DNA. These mismatches also have the potential to induce DNA damage including double-stranded breaks and chromosome translocations Mus musculus