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Literature summary for 3.5.4.38 extracted from

  • Pasqualucci, L.; Kitaura, Y.; Gu, H.; Dalla-Favera, R.
    PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells (2005), Proc. Natl. Acad. Sci. USA, 103, 395-400.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.38

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm activation-induced deaminase is present in a complex containing the regulatory subunit Ialpha and, possibly, the catalytic subunit of protein kinase A in the cytoplasm of B cells, suggesting that protein kinase A itself may contribute in part to the localization of AID in this compartment Homo sapiens 5737
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded DNA + H2O Homo sapiens
-
 uracil in single-stranded DNA + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9GZX7
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein protein kinase A phosphorylates activation-induced cytidine deaminase and regulates its activity in GC B cells. Phosphorylation targets specifically Thr27 and Ser38 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte germinal center B-cell Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded DNA + H2O
-
 Homo sapiens uracil in single-stranded DNA + NH3
-
 ?

Synonyms

Synonyms Comment Organism
activation-induced deaminase
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 Homo sapiens
AID
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 Homo sapiens