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Literature summary for 3.5.4.38 extracted from

  • Sohail, A.; Klapacz, J.; Samaranayake, M.; Ullah, A.; Bhagwat, A.S.
    Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations (2003), Nucleic Acids Res., 31, 2990-2994.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.38

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli. Human activation-induced cytidine deaminase purified from Escherichia coli is active without prior treatment with a ribonuclease and deaminates cytosines in plasmid DNA in vitro Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Homo sapiens
additional information no inbibition by EDTA Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
additional information the enzyme requires a tightly bound metal ion for its action Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded DNA + H2O Homo sapiens the enzyme can act on transcribing DNA. It is required for the maturation of antibodies in higher vertebrates, where it promotes somatic hypermutation uracil in single-stranded DNA + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9GZX7
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded DNA + H2O
-
 Homo sapiens uracil in single-stranded DNA + NH3
-
 ?
cytosine in single-stranded DNA + H2O the enzyme can act on transcribing DNA. It is required for the maturation of antibodies in higher vertebrates, where it promotes somatic hypermutation Homo sapiens uracil in single-stranded DNA + NH3
-
 ?

Synonyms

Synonyms Comment Organism
activation-induced deaminase
-
 Homo sapiens
AID
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is required for the maturation of antibodies in higher vertebrates, where it promotes somatic hypermutation Homo sapiens