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Literature summary for 3.5.4.38 extracted from

  • Basu, U.; Chaudhuri, J.; Alpert, C.; Dutt, S.; Ranganath, S.; Li, G.; Schrum, J.P.; Manis, J.P.; Alt, F.W.
    The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation (2005), Nature, 438, 508-511.
    View publication on PubMed
Search for more literature for 3.5.4.38

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus

Protein Variants

Protein Variants Comment Organism
S38A the kinetics of single-stranded DNA deaminase activity for wild-type and S38A mutant enzyme are comparable Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded DNA + H2O Mus musculus in response to antigens, B cells undergo two types of genomic alterations to increase antibody diversity. Affinity for antigen can be increased by introduction of point mutations into immunoglobulin heavy (IgH) and immunoglobulin light (IgL) variable regions by somatic hypermutation. Antibody effector functions can be altered by changing the expressed IgH constant region exons through IgH class switch recombination (CSR). Somatic hypermutation and CSR both require the B-cell-specific activation-induced cytidine deaminase protein (AID), which initiates these reactions through its single-stranded DNA-specific cytidine deaminase activity uracil in single-stranded DNA + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9WVE0
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein protein kinase A phosphorylates the Ser38. This phosphorylation event activates the enzyme to enable interaction with replication protein A, thereby augmenting the ability of activation-induced cytidine deaminase to effect class switch recombination in vivo Mus musculus

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded DNA + H2O
-
 Mus musculus uracil in single-stranded DNA + NH3
-
 ?
cytosine in single-stranded DNA + H2O in response to antigens, B cells undergo two types of genomic alterations to increase antibody diversity. Affinity for antigen can be increased by introduction of point mutations into immunoglobulin heavy (IgH) and immunoglobulin light (IgL) variable regions by somatic hypermutation. Antibody effector functions can be altered by changing the expressed IgH constant region exons through IgH class switch recombination (CSR). Somatic hypermutation and CSR both require the B-cell-specific activation-induced cytidine deaminase protein (AID), which initiates these reactions through its single-stranded DNA-specific cytidine deaminase activity Mus musculus uracil in single-stranded DNA + NH3
-
 ?

Synonyms

Synonyms Comment Organism
activation-induced cytidine deaminase
-
 Mus musculus
AID
-
 Mus musculus

General Information

General Information Comment Organism
physiological function in response to antigens, B cells undergo two types of genomic alterations to increase antibody diversity. Affinity for antigen can be increased by introduction of point mutations into immunoglobulin heavy (IgH) and immunoglobulin light (IgL) variable regions by somatic hypermutation. Antibody effector functions can be altered by changing the expressed IgH constant region exons through IgH class switch recombination (CSR). Somatic hypermutation and CSR both require the B-cell-specific activation-induced cytidine deaminase protein (AID), which initiates these reactions through its single-stranded DNA-specific cytidine deaminase activity Mus musculus