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Literature summary for 3.5.4.38 extracted from

  • Staszewski, O.; Baker, R.E.; Ucher, A.J.; Martier, R.; Stavnezer, J.; Guikema, J.E.
    Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig loci in activated B cells (2011), Mol. Cell., 41, 232-242.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.38

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded DNA + H2O Mus musculus the enzyme induces reproducible DNA breaks at many non-Ig loci in activated B cells uracil in single-stranded DNA + NH3
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Organism

Organism UniProt Comment Textmining
Mus musculus Q9WVE0
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Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded DNA + H2O the enzyme induces reproducible DNA breaks at many non-Ig loci in activated B cells Mus musculus uracil in single-stranded DNA + NH3
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 ?
cytosine in single-stranded DNA + H2O unlike AID-induced double-strand DNA breaks in immunoglobulin genes, genome-wide activation-induced cytidine deaminase-dependent double-strand DNA breaks are not restricted to transcribed regions and frequently occur within repeated sequence elements, including CA repeats, non-CA tandem repeats, and short interspersed element Mus musculus uracil in single-stranded DNA + NH3
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 ?

Synonyms

Synonyms Comment Organism
activation-induced cytidine deaminase
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 Mus musculus
AID
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 Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme induces reproducible DNA breaks at many non-Ig loci in activated B cells Mus musculus