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Literature summary for 3.5.4.38 extracted from

  • Muramatsu, M.; Sankaranand, V.S.; Anant, S.; Sugai, M.; Kinoshita, K.; Davidson, N.O.; Honjo, T.
    Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells (1999), J. Biol. Chem., 274, 18470-18476.
    View publication on PubMed
Search for more literature for 3.5.4.38

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24000
-
 x * 24000, calculation from sequence Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q9WVE0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CH12F3-2 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded DNA + H2O the enzyme does neither catalyzes cytidine to uridine editing of apoB mRNA nor binds to AU-rich RNA targets Mus musculus uracil in single-stranded DNA + NH3
-
 ?

Subunits

Subunits Comment Organism
? x * 24000, calculation from sequence Mus musculus

Synonyms

Synonyms Comment Organism
activation-induced deaminase
-
 Mus musculus
AID
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Mus musculus

Expression

Organism Comment Expression
Mus musculus expression of activation-induced cytidine deaminase mRNA is induced in splenic B cells that are activated in vitro or by immunizations with sheep red blood cells. In situ hybridization of immunized spleen sections reveals the restricted expression of AID mRNA in developing germinal centers in which modulation of immunoglobulin gene information through somatic hypermutation and class switch recombination takes place up