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Literature summary for 3.5.4.38 extracted from

  • Lee, S.A.; Parsa, J.Y.; Martin, A.; Baker, M.D.
    Activation-induced cytidine deaminase induces DNA break repair events more frequently in the Ig switch region than other sites in the mammalian genome (2007), Eur. J. Immunol., 37, 3529-3539.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
construction of stable transformants (mouse hybridoma cells) expressing human activation-induced cytidine deaminase Homo sapiens

Protein Variants

Protein Variants Comment Organism
C90A catalytically inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded DNA + H2O Homo sapiens activation-induced cytidine deaminase (AID) produces DNA breaks in immunoglobulin genes during antibody diversification. Double-stranded breaks in the switch region mediate class switch recombination, and contribute to gene conversion and somatic hypermutation in the variable regions. Among potential highly transcribed genes in mouse hybridoma cells, the immunoglobulin heavy and light chain genes are important AID targets, with the immunoglobulin mu switch region being preferred compared to other genomic sites uracil in single-stranded DNA + NH3
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q9GZX7
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded DNA + H2O activation-induced cytidine deaminase (AID) produces DNA breaks in immunoglobulin genes during antibody diversification. Double-stranded breaks in the switch region mediate class switch recombination, and contribute to gene conversion and somatic hypermutation in the variable regions. Among potential highly transcribed genes in mouse hybridoma cells, the immunoglobulin heavy and light chain genes are important AID targets, with the immunoglobulin mu switch region being preferred compared to other genomic sites Homo sapiens uracil in single-stranded DNA + NH3
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 ?
cytosine in single-stranded DNA + H2O among potential highly transcribed genes in mouse hybridoma cells, the immunoglobulin heavy and light chain genes are important targets, with the immunoglobulin mu switch region being preferred compared to other genomic sites Homo sapiens uracil in single-stranded DNA + NH3
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 ?

Synonyms

Synonyms Comment Organism
activation-induced deaminase
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 Homo sapiens
AID
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 Homo sapiens

General Information

General Information Comment Organism
physiological function activation-induced cytidine deaminase (AID) produces DNA breaks in immunoglobulin genes during antibody diversification. Double-stranded breaks (DSB) in the switch region mediate class switch recombination, and contribute to gene conversion and somatic hypermutation in the variable regions Homo sapiens