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Literature summary for 3.5.4.38 extracted from

  • Brar, S.S.; Sacho, E.J.; Tessmer, I.; Croteau, D.L.; Erie, D.A.; Diaz, M.
    Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA (2007), DNA Repair, 7, 77-87.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.38

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded DNA + H2O Homo sapiens the enzyme deaminates cytidine residues in the DNA of the variable and the switch regions of the immunoglobulin locus. The resulting uracil induces error-prone DNA synthesis in the case of hypermutation or DNA breaks that activate nonhomologous recombination in the case of class-switch recombination uracil in single-stranded DNA + NH3
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9GZX7
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded DNA + H2O the enzyme deaminates cytidine residues in the DNA of the variable and the switch regions of the immunoglobulin locus. The resulting uracil induces error-prone DNA synthesis in the case of hypermutation or DNA breaks that activate nonhomologous recombination in the case of class-switch recombination Homo sapiens uracil in single-stranded DNA + NH3
-
 ?
cytosine in single-stranded DNA + H2O the enzyme deaminates cytidine residues in the DNA of the variable and the switch regions of the immunoglobulin locus. The resulting uracil induces error-prone DNA synthesis in the case of hypermutation or DNA breaks that activate nonhomologous recombination in the case of class-switch recombination. The enzyme deaminates single-stranded but not double-stranded substrates unless it is in a complex with replication protein A (RPA) and the substrate is actively undergoing transcription Homo sapiens uracil in single-stranded DNA + NH3
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 ?

Subunits

Subunits Comment Organism
monomer non-phosphorylated activation-induced deaminase, is catalytically active as a monomer on single stranded DNA in vitro, including single-stranded DNA found in loops similar to those transiently formed in the immunoglobulin switch regions during transcription Homo sapiens

Synonyms

Synonyms Comment Organism
activation-induced deaminase
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 Homo sapiens
AID
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 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens