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Literature summary for 3.5.4.37 extracted from
- RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself (2015), Science, 349, 1115-1120 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E861A | editing-deficient knock-in mutation. Adar1(E861A/E861A) embryos die at embryonic day 13.5, with activated interferon and double-stranded RNA-sensing pathways | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q99MU3 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAR1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | A-to-I editing of endogenous dsRNA is the essential function of ADAR1, preventing the activation of the cytosolic dsRNA response by endogenous transcripts | Mus musculus |
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Release 2023.1 (January 2023)
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