Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P78563 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioma cell line | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ADAR2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | A-to-I underediting at the glutamine (Q)/arginine (R) site of the glutamate receptor subunit B (GluR-B) is associated with the pathogenesis and invasiveness of glioma and is confirmed in the glioma cell lines U87, U251 and A172 compared with that in normal human astrocytes. The expression of ADAR2 mRNA was not significantly altered in the glioma cell lines. Aberrant alternative splicing pattern of ADAR2 downregulates A-to-I editing in glioma | Homo sapiens |
metabolism | ADAR2 is the main enzyme responsible for A-to-I editing in humans | Homo sapiens |