Application | Comment | Organism |
---|---|---|
drug development | ADAR1 is a potential therapeutic target in a subset of cancers | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P55265 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
ADAR1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is an essential gene for the survival of a subset of cancer cell lines. ADAR1-dependent cell lines display increased expression of interferon-stimulated genes. Activation of type I interferon signaling in the context of ADAR1 deficiency can induce cell lethality in non-ADAR1-dependent cell lines | Homo sapiens |