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Literature summary for 3.5.4.37 extracted from

  • Gannon, H.S.; Zou, T.; Kiessling, M.K.; Gao, G.F.; Cai, D.; Choi, P.S.; Ivan, A.P.; Buchumenski, I.; Berger, A.C.; Goldstein, J.T.; Cherniack, A.D.; Vazquez, F.; Tsherniak, A.; Levanon, E.Y.; Hahn, W.C.; Meyerson, M.
    Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells (2018), Nat. Commun., 9, 5450 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development ADAR1 is a potential therapeutic target in a subset of cancers Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P55265
-
-

Synonyms

Synonyms Comment Organism
ADAR1
-
Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme is an essential gene for the survival of a subset of cancer cell lines. ADAR1-dependent cell lines display increased expression of interferon-stimulated genes. Activation of type I interferon signaling in the context of ADAR1 deficiency can induce cell lethality in non-ADAR1-dependent cell lines Homo sapiens