Cloned (Comment) | Organism |
---|---|
the Z-DNA binding domain is expressed as a C-terminal glutathione S-transferase fusion in Escherichia coli using a pGEX-5X1 cloning vector | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenine in double-stranded RNA + H2O | Homo sapiens | editing of RNA changes the read-out of information from DNA by altering the nucleotide sequence of a transcript. One type of RNA editing found in all metazoans uses double-stranded RNA (dsRNA) as a substrate and results in the deamination of adenosine to give inosine, which is translated as guanosine | hypoxanthine in double-stranded RNA + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenine in double-stranded RNA + H2O | editing of RNA changes the read-out of information from DNA by altering the nucleotide sequence of a transcript. One type of RNA editing found in all metazoans uses double-stranded RNA (dsRNA) as a substrate and results in the deamination of adenosine to give inosine, which is translated as guanosine | Homo sapiens | hypoxanthine in double-stranded RNA + NH3 | - |
? | |
adenine in double-stranded RNA + H2O | ADAR1 contains a domain (Zalpha) that binds specifically to the left-handed Z-DNA conformation with high affinity. As formation of Z-DNA in vivo occurs 5' to, or behind, a moving RNA polymerase during transcription, recognition of Z-DNA by DRADA1 provides a plausible mechanism by which DRADA1 can be targeted to a nascent RNA so that editing occurs before splicing | Homo sapiens | hypoxanthine in double-stranded RNA + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DRADA1 | - |
Homo sapiens |
dsRNA adenosine deaminase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | editing of RNA changes the read-out of information from DNA by altering the nucleotide sequence of a transcript. One type of RNA editing found in all metazoans uses double-stranded RNA (dsRNA) as a substrate and results in the deamination of adenosine to give inosine, which is translated as guanosine | Homo sapiens |