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Literature summary for 3.5.4.37 extracted from

  • Hartner, J.C.; Schmittwolf, C.; Kispert, A.; Müller, A.M.,; Higuchi, M.; Seeburg, P.H.
    Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1 (2004), J. Biol. Chem., 279, 4894-4902.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus Q99MU3
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Source Tissue

Source Tissue Comment Organism Textmining
embryo
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Mus musculus
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liver embryonic Mus musculus
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Synonyms

Synonyms Comment Organism
ADAR1
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Mus musculus

General Information

General Information Comment Organism
malfunction homozygosity for two different null alleles of ADAR1 causes a consistent embryonic phenotype appearing early at embryonic day 11 and leading to death between embryonic days 11.5 and 12.5. This phenotype manifests a rapidly disintegrating liver structure, along with severe defects in definitive hematopoiesis, encompassing both erythroid and myeloid/granuloid progenitors as well as spleen colonyforming activity from the aorta-gonad-mesonephros region and fetal liver Mus musculus