Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q99MU3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Mus musculus | - |
liver | embryonic | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
ADAR1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | homozygosity for two different null alleles of ADAR1 causes a consistent embryonic phenotype appearing early at embryonic day 11 and leading to death between embryonic days 11.5 and 12.5. This phenotype manifests a rapidly disintegrating liver structure, along with severe defects in definitive hematopoiesis, encompassing both erythroid and myeloid/granuloid progenitors as well as spleen colonyforming activity from the aorta-gonad-mesonephros region and fetal liver | Mus musculus |