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Literature summary for 3.5.4.37 extracted from

  • Cho, D.S.; Yang, W.; Lee, J.T.; Shiekhattar, R.; Murray, J.M.; Nishikura, K.
    Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA (2003), J. Biol. Chem., 278, 17093-17102.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf9 cells Homo sapiens
expression in Sf9 cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus nuclear extract Mus musculus 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
90000
-
2 * 90000, ADAR2 forms a stable enzymatically active homodimer complex, SDS-PAGE Homo sapiens
150000
-
2 * 150000, ADAR1 forms a stable enzymatically active homodimer complex, SDS-PAGE Homo sapiens
180000
-
gel filtration Homo sapiens
300000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P55265
-
-
Mus musculus Q99MU3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
HeLa cell
-
Homo sapiens
-

Subunits

Subunits Comment Organism
dimer 2 * 150000, ADAR1 forms a stable enzymatically active homodimer complex, SDS-PAGE Homo sapiens
dimer 2 * 90000, ADAR2 forms a stable enzymatically active homodimer complex, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ADAR
-
Mus musculus
ADAR1
-
Homo sapiens
ADAR2 ADAR2 lacks a part of the N-terminus region of ADAR1, upstream of its RNA binding domain, where ADAR1 contains two repeats of a Z-DNA binding motif Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens
30
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Homo sapiens
7
-
assay at Mus musculus