Literature summary for 3.5.4.34 extracted from

Maas, S.; Gerber, A.P.; Rich, A.
Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes (1999), Proc. Natl. Acad. Sci. USA, 96, 8895-8900.

Search for more literature for 3.5.4.34

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
adenine37 in tRNAAla + H2O	Homo sapiens	specifically deaminates adenosine 37 to inosine in eukaryotic tRNAAla. This unique modification in tRNAAla is conserved from yeast to man	hypoxanthine37 in tRNAAla + NH3	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BUB4	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	the enzyme is expressed ubiquitously in human tissues	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
adenine37 in tRNAAla + H2O	specifically deaminates adenosine 37 to inosine in eukaryotic tRNAAla. This unique modification in tRNAAla is conserved from yeast to man	Homo sapiens	hypoxanthine37 in tRNAAla + NH3	-	?
adenine37 in tRNAAla + H2O	in vitro, the recombinantly expressed and purified hADAT1 protein efficiently and specifically deaminates A37 in the anticodon loop of tRNAAla from higher eukaryotes and with lower efficiency from lower eukaryotes. It does not modify adenosines residing in double-stranded RNA or in pre-mRNAs that serve as substrates for ADAR1 or ADAR2. The anticodon stemloop of tRNAAla alone is not a functional substrate for hADAT1	Homo sapiens	hypoxanthine37 in tRNAAla + NH3	-	?

Synonyms

Synonyms	Comment	Organism
hADAT1	-	Homo sapiens

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Release 2023.1 (January 2023)