Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-benzyl-6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione | competitive; competitive, the presence of a benzyl group at position-3 enhances the inhibitory activity by greater than twofold as compared to that without the benzyl group | Oryctolagus cuniculus | |
6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione | competitive; competitive, the presence of a benzyl group at position-3 enhances the inhibitory activity by greater than twofold as compared to that without the benzyl group | Oryctolagus cuniculus | |
6-hydroxy-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione | i.e. azepinomycin | Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Oryctolagus cuniculus | |
0.00966 | - |
guanine | pH 7.4, 25°C | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanine + H2O | Oryctolagus cuniculus | - |
xanthine + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Oryctolagus cuniculus | - |
commercial preparation | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | from liver | Oryctolagus cuniculus | - |
liver | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanine + H2O | - |
Oryctolagus cuniculus | xanthine + NH3 | - |
? | |
guanine + H2O | reaction via tetrahedral intermediate | Oryctolagus cuniculus | xanthine + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GDA | - |
Oryctolagus cuniculus |
guanase | - |
Oryctolagus cuniculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Oryctolagus cuniculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Oryctolagus cuniculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0005 | - |
6-hydroxy-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione | pH 7.4, 25°C | Oryctolagus cuniculus | |
0.00201 | - |
3-benzyl-6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione | pH 7.4, 25°C | Oryctolagus cuniculus | |
0.00536 | - |
6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione | pH 7.4, 25°C | Oryctolagus cuniculus | |
0.02 | - |
3-benzyl-6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione | pH 7.4, 25°C | Oryctolagus cuniculus | |
0.054 | - |
6-(hydroxymethyl)-3,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione | pH 7.4, 25°C | Oryctolagus cuniculus |