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Literature summary for 3.5.4.3 extracted from
- Purification of rabbit liver guanine aminohydrolase (1975), Prep. Biochem., 5, 59-77.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-aminoimidazole-4-carboxamide | - |
Homo sapiens |  |
| 5-aminoimidazole-4-carboxamide | - |
Oryctolagus cuniculus | |
| 5-aminoimidazole-4-carboxamide | - |
Rattus norvegicus | |
| 9-(p-aminoethoxyphenyl)guanine | strong inhibitor | Oryctolagus cuniculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0056 | - |
guanine | - |
Homo sapiens | |
| 0.0056 | - |
guanine | at pH 8 | Oryctolagus cuniculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 26000 | - |
1 * 26000 + 1 * 49000 + 1 * 77000, SDS-PAGE | Oryctolagus cuniculus |
| 49000 | - |
1 * 26000 + 1 * 49000 + 1 * 77000, SDS-PAGE | Oryctolagus cuniculus |
| 77000 | - |
1 * 26000 + 1 * 49000 + 1 * 77000, SDS-PAGE | Oryctolagus cuniculus |
| 100000 | - |
gel filtration, different molecular weight polymers of the enzyme | Homo sapiens |
| 100000 | - |
gel filtration, different molecular weight polymers of the enzyme | Oryctolagus cuniculus |
| 117000 | - |
gel filtration, lower pH and lower ionic strength, 2 different polymers | Oryctolagus cuniculus |
| 207000 | - |
2 forms of liver enzyme | Oryctolagus cuniculus |
| 265000 | - |
gel filtration, lower pH and lower ionic strength, 2 different polymers | Oryctolagus cuniculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanine + H2O | Homo sapiens | - |
xanthine + NH3 | - |
? | |
| guanine + H2O | Rattus norvegicus | - |
xanthine + NH3 | - |
? | |
| guanine + H2O | Oryctolagus cuniculus | - |
xanthine + NH3 | - |
? | |
| guanine + H2O | Ophiodon elongatus | - |
xanthine + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
| Ophiodon elongatus | - |
lingcod | - |
| Oryctolagus cuniculus | - |
rabbit | - |
| Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Oryctolagus cuniculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Oryctolagus cuniculus | - |
| muscle | - |
Homo sapiens | - |
| muscle | - |
Ophiodon elongatus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 12.6 | - |
- |
Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanine + H2O | - |
Homo sapiens | xanthine + NH3 | - |
? | |
| guanine + H2O | - |
Rattus norvegicus | xanthine + NH3 | - |
? | |
| guanine + H2O | - |
Oryctolagus cuniculus | xanthine + NH3 | - |
? | |
| guanine + H2O | - |
Ophiodon elongatus | xanthine + NH3 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| oligomer | 1 * 26000 + 1 * 49000 + 1 * 77000, SDS-PAGE | Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Homo sapiens |
| 8 | - |
- |
Rattus norvegicus |
| 8 | - |
- |
Oryctolagus cuniculus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.6 | 9.5 | - |
Oryctolagus cuniculus |
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