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Literature summary for 3.5.4.3 extracted from
- Characterization of purified guanine aminohydrolase (1979), Arch. Biochem. Biophys., 194, 107-116.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-Deazaguanine | competitive inhibitor | Oryctolagus cuniculus |  |
| F- | inhibition decreases as pH increases, 50% activity was inhibited at pH 7.5, most of activity lost at pH 6.5 | Oryctolagus cuniculus | |
| p-hydroxymercuribenzoate | - |
Oryctolagus cuniculus | |
| Rose bengal | photo-oxidation, 0.00025% at acidic pH | Oryctolagus cuniculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0038 | - |
guanine | - |
Oryctolagus cuniculus | |
| 0.23 | - |
8-Azaguanine | - |
Oryctolagus cuniculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 52000 | - |
2 * 52000, brain and liver enzymes, SDS-PAGE | Oryctolagus cuniculus |
| 53020 | - |
calculated from amino acid analysis | Oryctolagus cuniculus |
| 55000 | - |
1 * 55000, gel filtration, SDS-PAGE | Oryctolagus cuniculus |
| 100000 | - |
- |
Oryctolagus cuniculus |
| 110000 | - |
liver, gel filtration | Oryctolagus cuniculus |
| 207000 | - |
- |
Oryctolagus cuniculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanine + H2O | Oryctolagus cuniculus | - |
xanthine + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
rabbit | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-thioguanine + H2O | - |
Oryctolagus cuniculus | 6-thioxanthine + NH3 | - |
? | |
| 8-azaguanine + H2O | - |
Oryctolagus cuniculus | 8-azaxanthine + NH3 | - |
? | |
| guanine + H2O | - |
Oryctolagus cuniculus | xanthine + NH3 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 52000, brain and liver enzymes, SDS-PAGE | Oryctolagus cuniculus |
| monomer | 1 * 55000, gel filtration, SDS-PAGE | Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Oryctolagus cuniculus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 10 | - |
Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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